It had been shut for around 9 hours
The M5 southbound has now reopened between junction 28 (Cullompton) and junction 29 (Exeter) following a serious incident earlier today.
The section of motorway in Devon has been closed to traffic since a serious incident at 6.45am.
Police have now completed their on-scene investigations and all three lanes were reopened just before 4pm.
An earlier incident also closed the M5 southbound between junction 25 (Taunton) and junction 26 (Wellington), the carriageway reopening at 10am, and the A30 was also reopened in Devon at 2pm following an early-morning incident between the A35 and A303 at Otter Vale.
Real-time traffic information for England’s motorways and major A roads is available from the web at www.highways.gov.uk/traffic or (when not driving) from a phone or mobile device at m.highways.gov.uk. Information is also available on Twitter at @HighwaysSWEST